Specification of neural crest cell formation and migration in mouse embryos.

نویسنده

  • Paul A Trainor
چکیده

Of all the model organisms used to study human development, rodents such as mice most accurately reflect human craniofacial development. Collective advances in mouse embryology and mouse genetics continue to shape our understanding of neural crest cell development and by extrapolation the etiology of human congenital head and facial birth defects. The aim of this review is to highlight the considerable progress being made in our understanding of cranial neural crest cell patterning in mouse embryos.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals

The role of planar cell polarity (PCP) signalling in neural crest (NC) development is unclear. The PCP dependence of NC cell migration has been reported in Xenopus and zebrafish, but NC migration has not been studied in mammalian PCP mutants. Vangl2(Lp/Lp) mouse embryos lack PCP signalling and undergo almost complete failure of neural tube closure. Here we show, however, that NC specification, ...

متن کامل

Dev111427 1..6

The role of planar cell polarity (PCP) signalling in neural crest (NC) development is unclear. The PCP dependence of NC cell migration has been reported inXenopus and zebrafish, but NCmigration has not been studied in mammalian PCP mutants. Vangl2 mouse embryos lack PCP signalling and undergo almost complete failure of neural tube closure. Here we show, however, that NC specification, migration...

متن کامل

Dev111427 3153..3158

The role of planar cell polarity (PCP) signalling in neural crest (NC) development is unclear. The PCP dependence of NC cell migration has been reported inXenopus and zebrafish, but NCmigration has not been studied in mammalian PCP mutants. Vangl2 mouse embryos lack PCP signalling and undergo almost complete failure of neural tube closure. Here we show, however, that NC specification, migration...

متن کامل

Many neural and non-neural cell types in vertebrates are produced by the neural crest, a transient embryonic structure that emerges during neurulation in the dorsal part of the neural tube (Le Douarin

INTRODUCTION Many neural and non-neural cell types in vertebrates are produced by the neural crest, a transient embryonic structure that emerges during neurulation in the dorsal part of the neural tube (Le Douarin et al., 2008). Among the neural crest derivatives are the pigment cells in the skin that are reported to originate either directly from neural crest cells migrating from the neural tu...

متن کامل

PFKFB4 control of AKT signaling is essential for premigratory and migratory neural crest formation.

Neural crest (NC) specification comprises an early phase, initiating immature NC progenitors formation at neural plate stage, and a later phase at neural fold stage, resulting in a functional premigratory NC that is able to delaminate and migrate. We found that the NC gene regulatory network triggers upregulation of pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4) during this lat...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Seminars in cell & developmental biology

دوره 16 6  شماره 

صفحات  -

تاریخ انتشار 2005